What Is the WES Test?
The WES Test (Whole Exome Sequencing) is an advanced genetic analysis used to examine the protein-coding regions of the human genome. These regions, known as exons, contain most of the mutations associated with inherited genetic diseases.
Although exons represent only a small part of the genome, they include the majority of disease-causing genetic variants. By analyzing thousands of genes at the same time, the WES Test allows specialists to identify potential genetic risks that may affect future pregnancies.
At Dogus IVF Center in Cyprus, this test may be recommended for patients who experience recurrent pregnancy loss, repeated IVF failure, or have a family history of inherited genetic conditions.
Why Is the WES Test Important?
The WES Test provides a detailed genetic analysis that can help identify hidden mutations and assess potential hereditary risks before pregnancy.
Identifying Hidden Carrier Mutations
Many individuals carry recessive genetic mutations without showing any symptoms. The test helps detect these mutations and evaluate whether they could affect future children.
Detecting Genetic Disease Risks
Inherited diseases are often caused by mutations in single genes. By analyzing thousands of genes simultaneously, WES testing can help identify these risks.
Supporting IVF Genetic Screening
If a mutation is detected, fertility specialists may recommend IVF combined with PGT-M (Preimplantation Genetic Testing for Monogenic Diseases) to select embryos without the mutation.
Investigating Recurrent Miscarriages
Some genetic mutations may interfere with early embryo development and lead to repeated pregnancy loss. Genetic sequencing may help identify these underlying causes.
Importance of WES Testing in Consanguineous Marriages
Consanguineous marriages (marriages between relatives) can increase the likelihood that both partners carry the same recessive genetic mutation.
When both parents carry the same mutation, the risk of passing a genetic disorder to their child increases. These inherited conditions may lead to:
- Congenital abnormalities
- Developmental delays
- Metabolic disorders
- Neuromuscular diseases
- Rare genetic syndromes
The WES Test helps identify these risks before pregnancy and supports safer family planning.
How Is the WES Test Performed?
The testing process involves several laboratory stages.
Sample Collection
A simple blood sample is taken to extract DNA from the patient.
Genetic Sequencing
Next Generation Sequencing (NGS) technology is used to analyze the entire exome region.
Bioinformatic Analysis
Thousands of genetic variants are compared with international genetic databases to identify clinically relevant mutations.
Genetic Counseling
Results are interpreted by genetic specialists who explain the findings and recommend possible next steps.
If necessary, IVF treatment with PGT-M genetic screening may be suggested.
Advantages of the WES Test
WES testing offers several advantages for couples planning pregnancy or fertility treatment.
- Comprehensive analysis of thousands of genes
- Identification of hidden carrier mutations
- Useful screening in consanguineous marriages
- Support for healthy pregnancy planning
- Personalized fertility treatment strategies
This detailed genetic information helps doctors design safer reproductive treatment plans.
Who Should Consider the WES Test?
The WES Test may be recommended for certain patient groups, including:
- Couples in consanguineous marriages
- Patients with recurrent miscarriages
- Couples with unexplained infertility
- Families with a history of genetic diseases
- Patients planning IVF treatment
- Couples concerned about congenital genetic disorders
A fertility specialist or genetic counselor can determine whether this test is appropriate based on the patient’s medical history.
WES Testing at Dogus IVF Center
At Dogus IVF Center Cyprus, WES testing is performed using advanced sequencing technologies and internationally recognized laboratory standards.
The evaluation process includes:
- High-precision Next Generation Sequencing technology
- Advanced bioinformatic analysis
- Clinical interpretation by genetic specialists
- Integration with PGT-M genetic testing when required
- Detailed genetic counseling for couples
By combining modern reproductive medicine with advanced genetic analysis, our goal is to help couples plan healthier pregnancies and improve IVF treatment outcomes.
