What Is NGS?
NGS (Next Generation Sequencing) is an advanced genetic testing technology used during IVF treatment to analyze embryos at the chromosomal level before embryo transfer.
With NGS testing, embryos created in the laboratory can be examined for chromosomal abnormalities. This allows fertility specialists to identify embryos with a normal chromosomal structure and select the most suitable embryo for transfer.
Because it analyzes the complete genetic structure of embryos, NGS in IVF treatment is considered one of the most comprehensive genetic screening technologies used in modern reproductive medicine.
NGS in IVF Treatment
During IVF treatment, fertilization takes place in the laboratory and embryos begin to develop. However, not every embryo has a normal chromosomal structure.
One of the most common reasons for failed embryo implantation or miscarriage is chromosomal abnormalities in embryos.
With NGS genetic testing, all 24 chromosomes of an embryo can be analyzed through comprehensive chromosome screening. This allows fertility specialists to:
- Detect embryos with chromosomal abnormalities
- Select genetically healthy embryos for transfer
- Improve implantation success rates
- Reduce miscarriage risk
Research shows that chromosomal abnormalities become more common with increasing maternal age. Genetic screening methods such as NGS testing help identify embryos with normal chromosomal structures and improve treatment outcomes.
Who Should Consider NGS Testing?
NGS testing may be recommended for certain patient groups undergoing IVF treatment.
It is particularly considered for patients who:
- Are 35 years or older
- Have experienced recurrent miscarriages
- Have had multiple failed IVF attempts
- Have unexplained infertility
- Carry structural chromosomal abnormalities such as translocations or inversions
- Experience severe male factor infertility
As maternal age increases, the risk of chromosomal abnormalities in embryos also rises. Genetic testing methods such as NGS in IVF help specialists identify embryos with normal chromosomal structures.
How Is NGS Testing Performed?
NGS testing is typically performed on embryos that reach the blastocyst stage, usually on day 5 or day 6 after egg retrieval.
Embryo Biopsy
A small number of cells are carefully removed from the outer layer of the blastocyst (trophectoderm). When performed by experienced embryologists, this biopsy does not harm embryo development.
Genetic Analysis
The collected cells are sent to a specialized genetic laboratory. Using Next Generation Sequencing technology, the chromosomal structure of the embryo is analyzed in detail.
Embryo Freezing
After biopsy, embryos are typically preserved using the vitrification freezing technique while genetic analysis is completed.
Once the results are available, embryos identified as chromosomally normal can be selected for embryo transfer.
Advantages of NGS Testing in IVF
Using NGS technology during IVF treatment provides several important advantages.
Higher Implantation Rates
Selecting chromosomally normal embryos increases the likelihood of successful implantation.
Reduced Miscarriage Risk
Many miscarriages are caused by chromosomal abnormalities. Genetic screening helps reduce this risk.
More Accurate Genetic Screening
Compared with older testing methods, NGS genetic testing provides highly detailed chromosome analysis.
Improved Pregnancy Outcomes
Transferring genetically healthy embryos reduces the risk of chromosomal disorders in newborns.
More Efficient IVF Treatment
Identifying the healthiest embryo earlier can reduce the number of IVF cycles required.
Can NGS Be Used for Gender Selection?
Since NGS testing analyzes the entire chromosomal structure of embryos, it can also determine sex chromosomes (XX or XY).
In some IVF treatments, this information may be used for gender selection, depending on medical indications and legal regulations.
NGS Testing at Dogus IVF Center
At Dogus IVF Center, advanced genetic screening technologies such as NGS testing are used when medically appropriate.
Our experienced embryology and genetics teams work together to evaluate embryo genetics and select embryos with the highest implantation potential.
If you would like more information about NGS testing in IVF, our specialists will be happy to guide you through the process and help you understand the most suitable treatment options.
